Tuesday, February 12, 2013

Relations

The Different

Following an attack on a village in a war zone, the natives and volunteers must escape with their lives...

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This topic is an Out Of Character part of the roleplay, ?The Different?. Anything posted here will also show up there.

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Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.
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[center][img]GIF here[/img]
[img]Go to fontmeme.com, generate a name for your character, and post it here.[/img]

? = romantic || ?= friends || ? = enemies || ? = neutral[/center]

[list]
[*][b]Alyssa Kendall:[/b] Your symbol first, then a little about the relationship. One or two sentences, unless it calls for more.
[*][b]Chris Enriquez:[/b] Your symbol first, then a little about the relationship. One or two sentences, unless it calls for more.
[*][b]Jay Sanders:[/b] Your symbol first, then a little about the relationship. One or two sentences, unless it calls for more.
[*][b]Patrick Amison:[/b] Your symbol first, then a little about the relationship. One or two sentences, unless it calls for more.
[*][b]Sylvia Rhodes:[/b] Your symbol first, then a little about the relationship. One or two sentences, unless it calls for more.
[*][b]Wren Baek:[/b] Your symbol first, then a little about the relationship. One or two sentences, unless it calls for more.
[*][b]Character Name:[/b] Slot in any characters added in alphabetical order.
[/list][/font]

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? = romantic || ?= friends || ? = enemies || ? = neutral

  • Alyssa Kendall: Your symbol first, then a little about the relationship. One or two sentences, unless it calls for more.
  • Chris Enriquez: ?/? Chris is a nice guy. He's pretty damn scary when he doesn't take his meds, and he's a little overwhelming, but you can't hate him.
  • Jay Sanders: ? I'm comfortable with who I am, I suppose.
  • Patrick Amison: Your symbol first, then a little about the relationship. One or two sentences, unless it calls for more.
  • Sylvia Rhodes: Your symbol first, then a little about the relationship. One or two sentences, unless it calls for more.
  • Wren Baek: ?/? She evidently wasn't there when I collapsed because of heatstroke. She appears to think that they would have been better off leaving me behind and that I'm slowing them down.

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? = romantic || ?= friends || ? = enemies || ? = neutral

  • Alyssa Kendall: Your symbol first, then a little about the relationship. One or two sentences, unless it calls for more.
  • Chris Enriquez: ?\? Sometimes I hate myself for my hyperactivity and violence.
  • Jay Sanders: ?\? Jay's a nice guy. He's quiet, and secretive. He gave us all one hell of a fright when he dropped with heatstroke, though.
  • Patrick Amison: Your symbol first, then a little about the relationship. One or two sentences, unless it calls for more.
  • Sylvia Rhodes: Your symbol first, then a little about the relationship. One or two sentences, unless it calls for more.
  • Wren Baek: ? We're different, but we've been friends for ages.

These violent delights have violent ends
And in their triumph die, like fire and powder,
Which, as they kiss, consume.

-Romeo and Juliet

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iCat
Member for 4 years





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Every Apple Product Supposedly in the Works

Did you hear the latest rumor about Apple's "explorations" into a Dick Tracy-like smartwatch that'll soon be attaching itself to everybody's wrists? It's coming soon. Or never. But it's just another one of an avalanche of products Apple is rumored to have in the works. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/46lLPXYVwgM/every-apple-product-supposedly-in-the-works

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Monday, February 11, 2013

Combining synthetic, natural toxins could disarm cancer, drug-resistant bacteria

Feb. 11, 2013 ? Cancer researchers from Rice University suggest that a new human-made drug that's already proven effective at killing cancer and drug-resistant bacteria could best deliver its knockout blow when used in combination with drugs made from naturally occurring toxins.

"One of the oldest tricks in fighting is the one-two punch -- you distract your opponent with one attack and deliver a knockout blow with another," said Jos? Onuchic of Rice's Center for Theoretical Biological Physics (CTBP). "Combinatorial drug therapies employ that strategy at a cellular level.

"A wealth of research in recent years has shown that both cancer and bacteria can mount sophisticated, coordinated defenses against almost any drug," said Onuchic, Rice's Harry C. and Olga K. Wiess Professor of Physics and Astronomy, professor of chemistry, and biochemistry and cell biology. "By combining drugs, particularly those that place stress on different parts of the cell, we expect it will be possible to knock out either cancer cells or bacteria while simultaneously inhibiting their ability to become drug-resistant."

Onuchic and CTBP colleagues Eshel Ben-Jacob and Patricia Jennings reached their conclusions after analyzing several studies on anti-microbial peptides (AMPs), corkscrew-shaped chains of amino acids that kill Gram-negative bacteria. The CTBP team's ideas appear this week in the Proceedings of the National Academy of Sciences (PNAS) as a commentary on new findings from MD Anderson Cancer Center about a promising synthetic AMP called D-KLAKLAK-2. In its new research, MD Anderson researchers found D-KLAKLAK-2, which was already known to kill cancer cells, is also an effective drug against antibiotic-resistant Gram-negative bacteria.

"AMPs are produced naturally by a number of animals to fight bacteria," said Ben-Jacob, professor of biochemistry and cell biology at Rice and the Maguy-Glass Chair in Physics of Complex Systems and professor of physics and astronomy at Tel Aviv University. "AMPs are corkscrew-shaped. They do not harm the animals' own cells, but they penetrate and shred the double-layered membranes of Gram-negative bacteria."

Gram-negative bacteria are a class of pathogens that includes drug-resistant varieties of bacteria that cause pneumonia, sepsis and other deadly diseases.

Ben-Jacob said cancer researchers have previously shown that they can tag AMPs with special "marker" molecules that allow the AMPs to penetrate and kill cancer cells. The markers allow the AMPs to be taken inside the cancer cells, something they cannot normally do.

"Once inside the cancer cells, the AMPs target and damage the cell's power plant, an organelle called the mitochondria, which has a double-layered membrane that is remarkably similar to that of Gram-negative bacteria," he said.

Though research has shown that AMPs can kill cancer cells, scientists are concerned that cancer cells could develop resistance to the compounds. In part, this concern arises from the fact that AMPs are fairly common in nature and that some organisms already have genetic mutations that allow them to evade AMP attacks.

To circumvent these natural defenses, MD Anderson researchers Wadih Arap and Renata Pasqualini led an effort a few years ago to create a synthetic version of a natural corkscrew-shaped AMP called KLAKLAK-2. Like all naturally occurring AMPs, KLAKLAK-2 has a left-handed twist -- much like the threads of a screw that turn clockwise. To make the molecule more difficult for cancer cells to fight, the MD Anderson team built a right-handed, "counterclockwise" version of the molecule called D-KLAKLAK-2, with the "D" denoting right-handedness. In its most recent studies, which also appear this week in PNAS, the MD Anderson team found that D-KLAKLAK-2 is an effective killer of Gram-negative bacterial pathogens, including several types that have grown resistant to traditional antibiotics.

"Bacteria are notorious for their rapid development of drug resistance," Ben-Jacob said. "However, both bacteria and cancer have impaired ability to resist these man-made 'mirror' compounds because they cannot use the machinery they have evolved to disarm the right-handed weapons."

Onuchic said another advantage of therapies involving synthetic AMPs like D-KLAKLAK-2 is that the drugs can be administered in extremely small doses, which will reduce side effects.

The Rice team suggests maximizing the benefits of synthetic AMPs by using them in drug cocktails that act like a one-two punch for either bacteria or cancer.

Naturally occurring AMPs are chemical weapons that bacteria themselves have developed over millions of years in their never-ending war among themselves. The team reasons that combining these natural toxins with human-made mirror drugs will create the drug equivalent of a one-two punch. The combination should "confuse" bacteria and cancer and prevent them from rapidly becoming resistant to the human-made drugs.

"Nature is smarter than we are," Ben-Jacob said. "Time and again, we have seen that seemingly simple cellular foes like bacteria and cancer can learn to mount effective defenses against any new drug we create. It is time to accept them as sophisticated enemies. We should attack them in much the same way that a well-trained boxer or military commander would go after a wily opponent -- with multiple, coordinated blows of very different kinds."

Jennings is professor of chemistry and biochemistry at the University of California, San Diego. Research at CTBP is supported by the National Science Foundation and by the Cancer Prevention and Research Institute of Texas.

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The above story is reprinted from materials provided by Rice University. The original article was written by Jade Boyd.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/JS4lMvoXLOs/130211162458.htm

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Mountain hunt for ex-LAPD cop enters 4th day

BIG BEAR LAKE, Calif. (AP) ? SWAT teams with air support and bloodhounds fanned out again Sunday in snow-covered mountains, searching for a former Los Angeles police officer suspected in three killings.

Authorities planned a 1 p.m. news conference in downtown Los Angeles to announce a reward for information leading to the arrest of Christopher Dorner, who has vowed revenge against several former LAPD colleagues whom he blames for ending his career.

On Saturday Chief Charlie Beck said officials would re-examine the allegations by Dorner, 33, that his law enforcement career was undone by racist colleagues. While he promised to hear out Dorner if he surrenders, Beck stressed that he was ordering a review of his 2007 case because he takes the allegation of racism in his department seriously.

"I do this not to appease a murderer. I do it to reassure the public that their police department is transparent and fair in all the things we do," the chief said in a statement.

Authorities suspect Dorner in a series of attacks in Southern California over the past week that left three people dead. Authorities say he has vowed revenge against several former LAPD colleagues whom he blames for ending his career. The killings and threats that Dorner allegedly made in an online rant have led police to provide protection to 50 families, Beck said.

A captain who was named a target in the manifesto posted on Facebook told the Orange County Register he has not stepped outside his house since he learned of the threat.

"From what I've seen of (Dorner's) actions, he feels he can make allegations for injustice and justify killing people and that's not reasonable," said Capt. Phil Tingirides, who chaired a board that stripped Dorner of his badge. "The end never justifies the means."

On Saturday, the scaled-back search party took advantage of a break from stormy weather to look for Dorner in the San Bernardino mountains, about 80 miles northeast of downtown Los Angeles, where his burned-out pickup truck was discovered Thursday. Officers went door-to-door to some 600 cabins in the ski resort area.

A law enforcement officer told The Associated Press authorities found weapons in the truck. The officer spoke on condition of anonymity because the probe is ongoing.

Investigators have been examining the truck to determine if it broke down or was set ablaze as a diversion. Police say the truck had a broken axle. Investigators are trying to determine whether it was already broken when they found it, or whether it was damaged when it was towed away.

Also, newly released surveillance video showed Dorner tossing several items into a Dumpster behind an auto parts store in National City on Monday. The store's manager told FOX5 in San Diego that an employee found a magazine full of bullets, a military belt and a military helmet. Majid Yahyai said he and the employee took the items across the street to a police station.

On Friday night, authorities served a search warrant and collected evidence from a Buena Park storage unit as part of their investigation. Irvine police Lt. Julia Engen wouldn't elaborate on the nature of the evidence or say who had rented the unit.

Earlier Friday, another warrant was served at a La Palma house belonging to Dorner's mother. Officers collected 10 bags of evidence, including five electronic items.

In his online manifesto, Dorner vowed to use "every bit of small arms training, demolition, ordnance and survival training I've been given" to bring "warfare" to the LAPD and its families.

Dorner served in the Navy, earning a rifle marksman ribbon and a pistol expert medal. He was assigned to a naval undersea warfare unit and various aviation training units, according to military records. He took leave from the LAPD for a six-month deployment to Bahrain in 2006 and 2007.

The flight training that he received in the Navy prompted the Transportation Security Administration to issue an alert, warning the general aviation community to be on the lookout for Dorner. The extent of his potential flying skills wasn't known, the bulletin said.

Feb. 1 was his last day with the Navy and also the day CNN's Anderson Cooper received a package that contained a note on it that read, in part, "I never lied." A coin riddled with bullet holes that former Chief William Bratton gave out as a souvenir was also in the package.

Police said it was a sign of planning by Dorner before the killing began.

On Feb. 3, police say Dorner shot and killed a couple in a parking garage at their condominium in Irvine. The woman was the daughter of a retired police captain who had represented Dorner in the disciplinary proceedings that led to his firing.

Dorner wrote in his manifesto that he believed the retired captain had represented the interests of the department over his.

Hours after authorities identified Dorner as a suspect in the double murder, police believe Dorner shot and grazed an LAPD officer in Corona and then used a rifle to ambush two Riverside police officers early Thursday, killing one and seriously wounding the other.

The crime spree spanned across a wide swath of Southern California, prompting several police agencies, including the FBI and US Marshall Service, to form a joint investigative task force.

___

Contributing to this report were Associated Press writers Christopher Weber, Greg Risling, Haven Daley, Michael Blood, John Antczak, Mark Evans and Julie Watson.

Abdollah can be reached at http://www.twitter.com/LATams.

Source: http://news.yahoo.com/mountain-hunt-ex-lapd-cop-enters-4th-day-084438786.html

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Sunday, February 10, 2013

Injured Utah athletes' families fear future without insurance | The Salt ...

(Rick Egan | The Salt Lake Tribune) Dale Lawrence, left, works on rehabilitation with Matt Hansen, right, at Neuroworx in South Jordan on Feb. 6, 2013. Lawrence was a wrestler at Wasatch High School in Heber when he was injured and paralyzed.

UHSAA ? Families of injured athletes fear a policy change that would eliminate catastrophic insurance.

Heber City ? These hands once squeezed Xbox controllers and braced falls from skateboards, folded and threw newspapers, grabbed tight to wrestlers and slammed them to the mat.

But now when Dale Lawrence gingerly lifts his left hand off the joystick that controls his wheelchair to softly greet a stranger, the simple action indicates progress, the result of two hard years of physical therapy.

Three times a week, the former Wasatch High wrestler makes the 45-minute trip from this quiet Utah valley to South Jordan for a few hours of exercise and workouts with machines that pump electrodes into his body. By the time early February comes around, the 20-year-old has exhausted the 15 sessions his family?s insurance covers each year.

That?s when catastrophic insurance takes over.

"They pick up what mine doesn?t," his mother, Kelly Giles, said of the policy the Utah High School Activities Association has carried since the mid-1990s. "Otherwise he wouldn?t be able to go back because we wouldn?t be able to afford it."

Lawrence, whose vertebrae snapped into his spinal cord during wrestling practice in January 2011, is one of roughly 15 people who have benefited from the UHSAA?s policy since it was put in place. This spring, the UHSAA?s Board of Trustees will decide whether to renew that policy amid concerns about rising premiums.

If the board elects to discontinue the policy, some worry it could create gaps in coverage for future athletes and students as individual schools and districts try to shoulder the load. Others simply say the $1 million policy isn?t enough to cover a lifetime of injuries.

???

Paying the premiums ? When the sponsorship that covered the UHSAA?s premiums dissolved, the association picked up the tab for its members. In recent years, half the revenue from football and basketball endowment games has covered most of that cost, while the association subsidizes the difference.

But two major claims ? first Lawrence?s injury, then the paralysis suffered by South Summit football player Porter Hancock in an October 2011 game ? have resulted in a jump in premiums from $90,000 to more than $130,000 in the past year. The cost ? about $3.50 per student ? has begun to drain the UHSAA?s endowment fund, leaving leaders to question whether the money should be spent on other things.

story continues below

"What a tremendous blessing and benefit it?s been to those families, but the premium continues to go up because of those payouts," UHSAA director Rob Cuff said. "It?s a great benefit. On the other hand, is it cost effective and can we service the students in a way that can affect more than just the ones who by chance get injured?"

The money could be put toward sportsmanship, student leadership initiatives or any number of other uses, Cuff said.

Board members are just beginning to examine the issue, and a vote likely won?t happen until sometime in March.

Region 14 trustee Matt Flinders, who represents South Summit, said he believes some districts would opt not to take on the cost of the insurance if the UHSAA stopped providing it. He said the association must find a way to continue the coverage, even if that means requiring districts and families to pay a portion of the cost.

"We can?t say we couldn?t buy this because we had to pay for some software," Flinders said.

?

Hit too hard? ? Lawrence loved football and wrestling, but it wasn?t his everything.

As a running back at Wasatch, he painted a superhero?s mask on his face with eyeblack, earning the nickname "Super Dale."

On the mat, Lawrence practiced more than he wrestled, he said. In seventh grade, the first time he put on a singlet, he misheard a coach?s instruction to exhibition wrestlers and never bothered to weigh in the entire year.

After that, he wrestled on and off with varying levels of enthusiasm, but he was excited to get back his junior year. He was a junior varsity captain and was winning more than he was losing while fluctuating between the 145- and 152-pound classes.

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Copyright 2013 The Salt Lake Tribune. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.sltrib.com/sltrib/tribpreps/55766460-190/lawrence-policy-insurance-dale.html.csp

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Tunisia: Pressure grows on Islamists to end crisis

TUNIS, Tunisia (AP) ? Calm is returning to the streets of Tunisia's capital, even as pressure is growing on the governing Islamists to find a solution to the country's biggest crisis since it set off the Arab Spring uprisings two years ago.

The killing of a Tunisian opposition leader last week brought protests against a government accused of pandering to extremists. The prime minister wants to appoint a new government of technocrats to ease tensions.

But his Ennahda party rejects the idea. Ennahda's governing committee is meeting Sunday to discuss it, amid signs of a growing split between party moderates and hard-liners.

After three days of street violence, the streets in the capital Tunis are relatively quiet Sunday, under the watchful eye of riot police.

Source: http://news.yahoo.com/tunisia-pressure-grows-islamists-end-crisis-130111445.html

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Saturday, February 9, 2013

Tunisian PM says new Cabinet needed during crisis

TUNIS, Tunisia (AP) ? Tunisia's Islamist prime minister said Saturday that he will resign if his proposal to appoint a nonpolitical Cabinet by mid-week is rejected.

Prime Minister Hamadi Jebali first called for that change on Wednesday after Tunisia was thrown into a crisis when a prominent opposition politician was shot and killed in Tunis, touching off violent protests.

Jebali's moderate Islamist Ennahda party has already rejected his proposal. But he didn't flinch, saying in an interview with the France-24 TV channel that to change the situation government ministers must be replaced by ones without a political affiliation, notably technocrats. "I feel obliged to save my country," he said, adding that Tunisia risks a "swing into chaos."

If his new team is accepted, "I will continue to assume my role," Jebali said. If not, he will withdraw from the government.

As Jabali spoke, several thousand pro-government protesters rallied on the main avenue of the capital. But outside Tunis, groups of youths threw stones at offices of the governing party and attacked police stations in several cities in scattered unrest.

The Interior Ministry said 230 people, aged 16 to 25, have been arrested since Friday, the day Chokri Belaid was buried. The slaying of the respected opposition figure unleashed anger, and his funeral drew hundreds of thousands of mourners chanting anti-government slogans in Tunis.

Saturday was the third straight day of unrest in this North African country, which overthrew its long-ruling president, Zine El Abidine Ben Ali, in January 2011, kicking off the Arab Spring revolutions.

With tensions mounting, Jebali said he'll appoint a new Cabinet by mid-week, saying it would be small, made up of technocrats and therefore neutral. He said that key ministries, notably Interior, Justice and Foreign Affairs, would not be spared. Those ministries are currently led by ministers from his Ennahda party.

He called the planned changes a "Cabinet reshuffle" that would avoid the complicated ? and riskier ? process of dissolving the government. Such a new government would need approval from Tunisia's Constituent Assembly.

But under Tunisian law, each new Cabinet minister also would still need individual approval from the Assembly ? where Jebali's Ennahda party has a majority.

Belaid, a human rights activist and one of Ennahda's most outspoken critics, was shot to death in his car outside his home on Wednesday, and his killers have not been identified.

The assassination has added to the growing turmoil in Tunisia, where the transition from dictatorship to democracy has been shaken by religious divides, political wrangling and economic struggles.

Hopes had been high that Tunisia could be a model for other Arab states finding their way in the Arab Spring. In the two years since, Ennahda, a moderate Islamist party, has won elections and governed in a coalition with two secular parties. However, there are growing signs of divisions within the party, made more visible after Belaid's killing.

Saturday saw pockets of pillaging and unrest, including an attack by some 80 youths armed with stones and clubs on a police station and a second security post in Zaghouan, 25 miles (40 kilometers) west of Tunis, the official TAP news agency reported. To the south, in the town of Kebili, some 60 people, mainly youths, attacked the governing Ennahda party offices. The extent of that damage was not immediately known.

Meanwhile, several thousand supporters of Ennahda held a pro-government demonstration in the capital on Saturday. The protesters also insulted France, accusing the former colonial ruler of interfering in the North African country's politics.

The Ennahda party had called for the show of support for the constitutional assembly, whose work on a new constitution suffered a severe setback after Belaid's killing when the opposition withdrew its participation.

The Ennahda party said Saturday's rally also was meant to protest "French interference," a reference to French Interior Minister Manuel Valls, who this week denounced Belaid's killing as an attack on "the values of Tunisia's Jasmine revolution."

The protesters denounced Valls' remarks, claiming they showed France is interfering in Tunisia's internal affairs. The demonstrators gathered in front of the National Theater, waving flags of the Ennahda party and shouting "Get out, France!"

The main thoroughfare was bustling, with cafes full and shops reopened after a general strike Friday. Police in riot armor and plainclothes officers patrolled, but the protest was peaceful ? in contrast to the aftermath of Friday's funeral when police fired tear gas amid running street battles in Tunis.

Valls said on Europe 1 radio Thursday that Belaid was "one of the democrats and we must support these democrats so that the values of the Jasmine Revolution are not betrayed. There is an Islamic fascism rising everywhere, but this obscurantism must, of course, be condemned because it denies the democracy for which the Libyan, Tunisian and Egyptian people have fought."

Valls was clearly referring to Salafists, with their strict interpretation of Islam, who have come to the fore and smeared Ennahda's moderate image. At least one black Salafi flag was spotted in the sea of white Ennahda flags at Saturday's demonstration, which took place near the well-guarded French Embassy.

Fathi Rhayem, a teacher, said the demonstration "shows the Tunisian peoples' desire to show that it is sovereign, it is independent and is no longer under French protection." He said, "We want to show that we want to live on equal terms with France, as friends with reciprocal interests but not like a dominant and a dominated. The policy of submission ... is finished now."

Source: http://news.yahoo.com/tunisian-pm-says-cabinet-needed-during-crisis-190424262.html

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